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📘 Test banks | Nursing
CELLULAR AND MOLECULAR IMMUNOLOGY 8TH EDITION ABBAS TEST BANK
📄 SKU: NURSING | Pages: 6 | Year: 2022
📋 Document Brief Description
Abbas: Cellular and Molecular Immunology, 8th Edition
Activation of T Lymphocytes
Test Bank
Multiple Choice
1. All of the following protein-protei...
Abbas: Cellular and Molecular Immunology, 8th Edition
Activation of T Lymphocytes
Test Bank
Multiple Choice
1. All of the following protein-protein interactions are involved in activation of naive
helper T cells by antigen-presenting cells (APCs) EXCEPT binding of:
A. Peptide-MHC complexes on the APC to the TCR on the T cell
B. CD4 on the T cell to nonpolymorphic regions of class II MHC molecules on the
APC
C. Integrins on the T cell with adhesion ligands on the APC
D. B7-2 on the APC with CD28 on the T cell
E. CD40L on the T cell with CD40 on the APC
ANS: E. CD40L is not expressed on naive T cells and is only up-regulated subsequent to
activation by an antigen-presenting cell (APC). In the naive helper T cell, the TCR binds
to the MHC-peptide complex whereas the CD4 coreceptor engages a conserved region on
the MHC II molecule. Integrins on the T cell interact with adhesion ligands on the APC.
This region of binding between the T cell and the APC is known as the immunologic
synapse and also includes costimulatory interactions, such as CD28 on the T cell binding
to B7 on the APC.
2. Which one of the following statements about MHC-TCR interactions is NOT true?
A. Antigen receptors on T cells bind to MHC molecules for only brief periods of
time.
B. The affinity of most TCRs for peptide-MHC complexes is similar to the affinity
of antibodies for their antigens.
C. Only 1% or less of the MHC molecules on any antigen-presenting cell (APC)
display a peptide recognized by a particular T cell.
D. T cells usually require multiple engagements with an APC before a threshold of
activation is reached.
E. A subthreshold number of MHC-TCR interactions can lead to T cell inactivation.
ANS: B. In general, the TCR binds to peptide-MHC complexes with lower affinity than
antigen-antibody interactions. This relatively low-affinity interaction occurs briefly; thus,
a T cell may need multiple engagements with the antigen-presenting cell (APC) before a
threshold of activation occurs. If this threshold is not reached, the T cell may enter into an
inactive state known as anergy. On any given APC, less than 1% of the MHC molecules
display the same peptide.
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